Pengaruh Olahraga Intensitas High dan Intensitas Moderate Dengan Musik terhadap TNF-α
DOI:
https://doi.org/10.17977/um062v3i82021p642-655Keywords:
moderate exercise, high exercise, music, TNF-α, olahraga moderat, olahraga high, musikAbstract
Abstract: High concentrations of tumor necrosis factor-α (TNF-α) can lead to insulin resistance. Exercise has been shown to improve the body's physiology. The purpose of this study was to compare the expression of TNF-α in high, moderate, and moderate intensity exercise with listening to music. This research is an experimental laboratory study, with a total sample of 45 men aged 19-23 years who were divided into 3 groups, namely the high, moderate, and moderate intensity exercise group with music. Analysis of blood sample data was then processed using the Special Science Statistical Package (SPSS) computer program. The results of data analysis showed that high intensity had no effect on TNF-α (P is 0.218). Moderate intensity exercise did not result in a significant decrease in TNF-α levels (P is 0.08). Moderate intensity exercise with music had a significant effect on decreasing TNF-α levels (P is 0.028). From these data, it shows that moderate exercise by listening to music can reduce TNF-α levels.
Abstrak: Konsentrasi Tumor necrosis factor-α (TNF-α) yang tinggi dapat mengakibatkan resistensi insulin. Olahraga terbukti dapat memperbaiki kondisi fisiologi tubuh. Tujuan dari penelitian ini yaitu membandingkan ekspresi TNF-α pada olahraga intensitas high, moderate, dan moderate dengan mendengar-kan musik. Penelitian ini adalah penelitian experimental laboratories, dengan jumlah sampel 45 pria berumur 19-23 tahun yang dibagi menjadi 3 kelompok, yaitu kelompok olahraga intensitas high, moderate, dan moderate dengan musik. Data analisis sampel darah kemudian diolah menggunakan program komputer Statistical Package of Special Science (SPSS). Hasil analisis data menunjukkan bahwa, olahraga intensitas high tidak berpengaruh terhadap TNF-α (P adalah 0,218). Olahraga intensitas moderate tidak mengakibatkan penurunan yang signifikan pada kadar TNF-α (P adalah 0,08). Olahraga intensitas moderate dengan musik, berpengaruh secara signifikan terhadap penurunan kadar TNF-α (P adalah 0,028). Dari data tersebut menunjukkan bahwa, olahraga intensitas moderate dengan mendengarkan musik, dapat menurunkan kadar TNF-α.
References
Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nature reviews immunology, 3(9), 745-756.
Allen, J., Sun, Y., & Woods, J. A. (2015). Exercise and the regulation of inflammatory responses. Progress in molecular biology and translational science, 135, 337-354.
Barker, K., & Eickmeyer, S. (2020). Therapeutic exercise. Med Clin North Am, 104(2), 189-198.
Boghrabadi, V., Hejazi, S. M., Gonabadi, A. H., Sanian, H., & Aminian, F. (2012). Effects of moderate-intensity exercise on serum proinflammatory cytokine levels in obese and non-obese men. Life Sci J, 9(3), 2529-2532.
Brownley, K. A., McMurray, R. G., & Hackney, A. C. (1995). Effects of music on physiological and affective responses to graded treadmill exercise in trained and untrained runners. International journal of psychophysiology, 19(3), 193-201.
Cechella, J. L., Leite, M. R., Dobrachinski, F., Da Rocha, J. T., Carvalho, N. R., Duarte, M. M., ... & Zeni, G. (2014). Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. Amino acids, 46(5), 1187-1195.
Chadorneshin, H. T., Cheragh-Birjandi, S., Goodarzy, S., & Ahmadabadi, F. (2019). The impact of high intensity interval training on serum chemerin, tumor necrosis factor-alpha and insulin resistance in overweight women. Obesity medicine, 14, 100101.
Clark, A., & Mach, N. (2016). Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes. Journal of the International Society of Sports Nutrition, 13(1), 1-21.
Clément, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., ... & Langin, D. (2004). Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects. The FASEB Journal, 18(14), 1657-1669.
Eickmeyer, S. M., Gamble, G. L., Shahpar, S., & Do, K. D. (2012). The role and efficacy of exercise in persons with cancer. PM&R, 4(11), 874-881.
Goldhammer, E., Tanchilevitch, A., Maor, I., Beniamini, Y., Rosenschein, U., & Sagiv, M. (2005). Exercise training modulates cytokines activity in coronary heart disease patients. International journal of cardiology, 100(1), 93-99.
Green, A., Rumberger, J. M., Stuart, C. A., & Ruhoff, M. S. (2004). Stimulation of lipolysis by tumor necrosis factor-α in 3T3-L1 adipocytes is glucose dependent: Implications for long-term regulation of lipolysis. Diabetes, 53(1), 74-81.
Gutch, M., Kumar, S., Razi, S. M., Gupta, K. K., & Gupta, A. (2015). Assessment of insulin sensitivity/resistance. Indian journal of endocrinology and metabolism, 19(1), 160.
Halson, S. L., Lancaster, G. I., Jeukendrup, A. E., & Gleeson, M. (2003). Immunological responses to overreaching in cyclists. Medicine & Science in Sports & Exercise, 35(5), 854-861.
Hollander, J., Fiebig, R., Gore, M., Ookawara, T., Ohno, H., & Ji, L. (2001). Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle. Pflügers Archiv, 442(3), 426-434.
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996). IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science, 271(5249), 665-670.
Jung, S. H., Park, H. S., Kim, K. S., Choi, W. H., Ahn, C. W., Kim, B. T., ... & Lee, K. W. (2008). Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. The Journal of nutritional biochemistry, 19(6), 371-375.
Kharraz, Y., Guerra, J., Mann, C. J., Serrano, A. L., & Muñoz-Cánoves, P. (2013). Macrophage plasticity and the role of inflammation in skeletal muscle repair. Mediators of inflammation, 2013.
Kramer, H. F., & Goodyear, L. J. (2007). Exercise, MAPK, and NF-κB signaling in skeletal muscle. Journal of applied physiology, 103(1), 388-395.
Kumar, S. A., Maiya, A. G., Shastry, B. A., Vaishali, K., Ravishankar, N., Hazari, A., ... & Jadhav, R. (2018). Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, 62(1), 1-6.
Leggate, M., Carter, W. G., Evans, M. J., Vennard, R. A., Sribala-Sundaram, S., & Nimmo, M. A. (2012). Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology, 112(8), 1353-1360.
Lloyd, J. W., Evans, K. A., Zerfass, K. M., Holmstrup, M. E., Kanaley, J. A., & Keslacy, S. (2016). Effect of an acute bout of aerobic exercise on chemerin levels in obese adults. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 10(1), 37-42.
Merawati, D., Kinanti, R. G., Susanto, H., & Taufiq, A. (2018, September). The attenuation of physical-physiological stresses through musical-high intensity exercise co-treatment in non-athlete individual. In Journal of Physics: Conference Series (Vol. 1093, No. 1, p. 012026). IOP Publishing.
Moldoveanu, A. I., Shephard, R. J., & Shek, P. N. (2001). The cytokine response to physical activity and training. Sports medicine, 31(2), 115-144.
Monzillo, L. U., Hamdy, O., Horton, E. S., Ledbury, S., Mullooly, C., Jarema, C., ... & Mantzoros, C. S. (2003). Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity research, 11(9), 1048-1054.
Niess, A. M., & Simon, P. (2007). Response and adaptation of skeletal muscle to exercise–the role of reactive oxygen species. Front Biosci, 12(12), 4826-38.
Park, S. E., Rhee, E. J., Park, C. Y., Oh, K. W., Park, S. W., Kim, S. W., & Lee, W. Y. (2013). Impact of hyperinsulinemia on the development of hypertension in normotensive, nondiabetic adults: a 4-year follow-up study. Metabolism, 62(4), 532-538.
Petersen, A. M. W., & Pedersen, B. K. (2005). The anti-inflammatory effect of exercise. Journal of applied physiology, 98(4), 1154-1162.
Powers, S. K., Howley, E. T., & Quindry, J. (2007). Exercise physiology: Theory and application to fitness and performance (p. 640). New York, NY: McGraw-Hill.
Proske, U., & Allen, T. J. (2005). Damage to skeletal muscle from eccentric exercise. Exercise and sport sciences reviews, 33(2), 98-104.
Proske, U., & Morgan, D. L. (2001). Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications. The Journal of physiology, 537(2), 333-345.
Riskesdas, (2018). Hasil Utama RISKESDAS 2018, (Online), (www.kesmas.kemkes.go.id > …PDF Hasil web Riskesdas 2018 – Kesmas Kemkes), diakses 1 Desember 2018.
Schütze, S., Berkovic, D., Tomsing, O., Unger, C., & Krönke, M. (1991). Tumor necrosis factor induces rapid production of 1'2'diacylglycerol by a phosphatidylcholine-specific phospholipase C. The Journal of experimental medicine, 174(5), 975-988.
Sjöholm, Å., & Nyström, T. (2006). Inflammation and the etiology of type 2 diabetes. Diabetes/metabolism research and reviews, 22(1), 4-10.
TaheriChadorneshin, H., Cheragh-Birjandi, S., Goodarzy, S., & Ahmadabadi, F. (2019). The impact of high intensity interval training on serum chemerin, tumor necrosis factor-alpha and insulin resistance in overweight women. Obesity medicine, 14, 100101
Thyfault, J. P., & Booth, F. W. (2011). Lack of regular physical exercise or too much inactivity. Current Opinion in Clinical Nutrition & Metabolic Care, 14(4), 374-378.
Usui, T., Yoshikawa, T., Ueda, S. Y., Katsura, Y., Orita, K., & Fujimoto, S. (2011). Effects of acute prolonged strenuous exercise on the salivary stress markers and inflammatory cytokines. Japanese Journal of Physical Fitness and Sports Medicine, 60(3), 295-304.
Wretman, C., Lionikas, A., Widegren, U., Lännergren, J., Westerblad, H., & Henriksson, J. (2001). Effects of concentric and eccentric contractions on phosphorylation of MAPKerk1/2 and MAPKp38 in isolated rat skeletal muscle. The Journal of physiology, 535(1), 155-164.
Yamasaki, A., Booker, A., Kapur, V., Tilt, A., Niess, H., Lillemoe, K. D., ... & Conrad, C. (2012). The impact of music on metabolism. Nutrition, 28(11-12), 1075-1080.
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., ... & Shulman, G. I. (2002). Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. Journal of Biological Chemistry, 277(52), 50230-50236
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