Association Of Resistin and Adiponectin Levels with Physiological and Inflammatory Parameters in Women with Rheumatoid Arthritis in Wasit Province, Iraq

Authors

  • Nada Hameed Ajam AL-Badri Department of Pathological Analysis, College of Science, Wasit University, Wasit, Iraq
  • Eman H. Al-Fadhili Department of Pathological Analysis, College of Science, Wasit University, Wasit, Iraq

DOI:

https://doi.org/10.17977/um067v6i82026p2

Keywords:

Resistin, Adiponectin, Rheumatoid Arthritis, CRP, ESR, TNF-α, IL-6, Lipid Profile

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting the whole body with the presence of constant inflammation at the joints and increased levels of inflammatory mediators while not maintaining normal metabolic homeostasis. The adipokines, such as resistin and adiponectin, secreted by adipose tissue, have been identified as important modulators of inflammatory and immune responses. Their involvement in the RA pathophysiology is not fully understood, especially in Middle Eastern populations. The aim of this study was to evaluate the levels of resistin and adiponectin in the serum of Iraqi women with RA who live in Wasit Province, Iraq, and determine their correlation with inflammatory biomarkers (CRP, ESR, TNF-α, and IL-6), lipid profile (total cholesterol, triglycerides, HDL-C, and LDL-C), and complete blood count (CBC) parameters (Hb, WBC, platelet count, MCV, MCH, and MCHC). The case-control study was carried out at Al-Kut Teaching Hospital and some private clinical laboratories in Al-Kut city, which comprised 60 women with RA (mean age 42.3 ± 8.7 years) and 30 healthy female controls (mean age 40.1 ± 7.9 years). The levels of serum resistin and serum adiponectin were measured using ELISA. Standard laboratory procedures were used to measure inflammatory markers, lipid profiles, and CBC. The Disease Activity Score-28 (DAS28) was used to measure disease activity. Serum resistin was significantly elevated in RA patients (18.6 ± 5.3 ng/mL) compared to controls (7.2 ± 2.1 ng/mL; p<0.001), while adiponectin was significantly reduced (8.4 ± 3.7 vs. 15.9 ± 4.2 μg/mL; p<0.001). Resistin correlated positively with CRP (r=+0.74), ESR (r=+0.68), TNF-α (r=+0.71), IL-6 (r=+0.66), and DAS28 (r=+0.69). Adiponectin inversely correlated with the same parameters. Dyslipidemia (increased LDL-C, triglycerides, decreased HDL-C) and hematological abnormalities were noted in RA patients. Resistin and adiponectin are significantly dysregulated in Iraqi women with RA and closely approximate disease activity and systemic inflammatory load. These adipokines could serve as potential complementary markers for disease severity and metabolic complications of RA.

References

Agca, R., Heslinga, S. C., Rollefstad, S., et al. (2017). EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 76(1), 17–28. https://doi.org/10.1136/annrheumdis-2016-209775 DOI: https://doi.org/10.1136/annrheumdis-2016-209775

Aletaha, D., Neogi, T., Silman, A. J., et al. (2010). 2010 Rheumatoid Arthritis Classification Criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Annals of the Rheumatic Diseases, 69(9), 1580–1588. https://doi.org/10.1136/ard.2010.138461 DOI: https://doi.org/10.1136/ard.2010.138461

Al-Mousawi, Z. H., & Al-Tamimi, F. A. (2023). Environmental heavy metal contamination in Wasit Province and immunological implications: A cross-sectional study. Journal of Wasit Science and Medicine, 16(2), 88–97.

Al-Tamimi, F. A., Sarbout, A. K., & Al-Rubai, N. J. (2022). Heavy metal contamination in agricultural soils of Wasit Governorate, Iraq: Implications for public health. Iraqi Journal of Science, 63(8), 3211–3219.

Almutairi, K. B., Nossent, J. C., Preen, D. B., Keen, H. I., & Inderjeeth, C. A. (2021). The prevalence of rheumatoid arthritis: A systematic review of population-based studies. Journal of Rheumatology, 48(5), 669–676. https://doi.org/10.3899/jrheum.200367 DOI: https://doi.org/10.3899/jrheum.200367

Bokarewa, M., Nagaev, I., Dahlberg, L., Smith, U., & Tarkowski, A. (2005). Resistin, an adipokine with potent proinflammatory properties. Journal of Immunology, 174(9), 5789–5795. https://doi.org/10.4049/jimmunol.174.9.5789 DOI: https://doi.org/10.4049/jimmunol.174.9.5789

Bruun, J. M., Lihn, A. S., Verdich, C., et al. (2003). Regulation of adiponectin by adipose tissue-derived cytokines: In vivo and in vitro investigations in humans. American Journal of Physiology: Endocrinology and Metabolism, 285(3), E527–E533. https://doi.org/10.1152/ajpendo.00110.2003 DOI: https://doi.org/10.1152/ajpendo.00110.2003

Burnett, J. R., & Hooper, A. J. (2006). Resistin and coronary artery disease. Clinical Science, 111(3), 229–231. https://doi.org/10.1042/CS20060162

Choy, E., & Sattar, N. (2009). Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: A challenge to conventional cardiovascular risk actions. Annals of the Rheumatic Diseases, 68(4), 460–469. https://doi.org/10.1136/ard.2008.101964 DOI: https://doi.org/10.1136/ard.2008.101964

Dong, S. S., Duan, Y. Y., Hu, Y. M., et al. (2019). Serum resistin and adiponectin levels and their correlation with disease activity in rheumatoid arthritis. Journal of Clinical Laboratory Analysis, 33(4), e22848. https://doi.org/10.1002/jcla.22848 DOI: https://doi.org/10.1002/jcla.22848

Fantuzzi, G. (2005). Adipose tissue, adipokines, and inflammation. Journal of Allergy and Clinical Immunology, 115(5), 911–919. https://doi.org/10.1016/j.jaci.2005.02.023 DOI: https://doi.org/10.1016/j.jaci.2005.02.023

Filkova, M., Haluzik, M., Gay, S., & Senolt, L. (2009). The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clinical Immunology, 133(2), 157–170. https://doi.org/10.1016/j.clim.2009.07.013 DOI: https://doi.org/10.1016/j.clim.2009.07.013

Härle, P., Sarzi-Puttini, P., Cutolo, M., & Straub, R. H. (2006). No evidence of quantitative alterations of adiponectin in serum and synovial fluid of patients with rheumatoid arthritis. Rheumatology International, 26(9), 845–848. https://doi.org/10.1007/s00296-005-0073-x

Harrison, P., & Goodall, A. H. (2008). 'Message in the platelet' — more than just vesicles? Platelets, 19(6), 395–404. https://doi.org/10.1080/09537100802193673 DOI: https://doi.org/10.1080/09537100801990582

McInnes, I. B., & Schett, G. (2017). Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet, 389(10086), 2328–2337. https://doi.org/10.1016/S0140-6736(17)31472-1 DOI: https://doi.org/10.1016/S0140-6736(17)31472-1

Migita, K., Maeda, Y., Miyashita, T., et al. (2006). The serum levels of resistin in rheumatoid arthritis patients. Clinical and Experimental Rheumatology, 24(6), 698–701.

Nemeth, E., & Ganz, T. (2014). Anemia of inflammation. Hematology/Oncology Clinics of North America, 28(4), 671–681. https://doi.org/10.1016/j.hoc.2014.04.005 DOI: https://doi.org/10.1016/j.hoc.2014.04.005

Prevoo, M. L., van't Hof, M. A., Kuper, H. H., van Leeuwen, M. A., van de Putte, L. B., & van Riel, P. L. (1995). Modified disease activity scores that include twenty-eight-joint counts. Arthritis & Rheumatism, 38(1), 44–48. https://doi.org/10.1002/art.1780380107 DOI: https://doi.org/10.1002/art.1780380107

Qin, Y., Zhang, W., Zhao, L., et al. (2022). Resistin in rheumatoid arthritis. Modern Rheumatology, 32(3), 554–563. https://doi.org/10.1093/mr/roab025 DOI: https://doi.org/10.1093/mr/roab025

Schäffler, A., Müller-Ladner, U., Schölmerich, J., & Büchler, C. (2006). Role of adipose tissue as an inflammatory organ in human diseases. Endocrine Reviews, 27(5), 449–467. https://doi.org/10.1210/er.2005-0022 DOI: https://doi.org/10.1210/er.2005-0022

Senolt, L., Pavelka, K., Housa, D., & Haluzík, M. (2006). Increased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritis. Cytokine, 35(5-6), 247–252. https://doi.org/10.1016/j.cyto.2006.09.006 DOI: https://doi.org/10.1016/j.cyto.2006.09.002

Serelis, J., Kontogianni, M. D., Katsiougiannis, S., et al. (2008). Effect of biologic treatment on body composition and serum adipokines of female patients with rheumatoid arthritis. Clinical Rheumatology, 27(7), 885–891. https://doi.org/10.1007/s10067-007-0801-7 DOI: https://doi.org/10.1007/s10067-008-0855-7

Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016). Rheumatoid arthritis. Lancet, 388(10055), 2023–2038. https://doi.org/10.1016/S0140-6736(16)30173-8 DOI: https://doi.org/10.1016/S0140-6736(16)30173-8

Tilg, H., & Moschen, A. R. (2006). Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology, 6(10), 772–783. https://doi.org/10.1038/nri1937 DOI: https://doi.org/10.1038/nri1937

Zhao, S., Wu, D., Ma, L., Li, X., & Li, Y. (2018). Association between resistin and rheumatoid arthritis: A meta-analysis and systematic review. Clinica Chimica Acta, 483, 270–275. https://doi.org/10.1016/j.cca.2018.05.016 DOI: https://doi.org/10.1016/j.cca.2018.05.016

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Published

13-07-2026

How to Cite

AL-Badri , N. H. A. ., & Al-Fadhili, E. H. . (2026). Association Of Resistin and Adiponectin Levels with Physiological and Inflammatory Parameters in Women with Rheumatoid Arthritis in Wasit Province, Iraq . Jurnal MIPA Dan Pembelajarannya, 6(8), 2. https://doi.org/10.17977/um067v6i82026p2

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Vol. 6 No. 8 (2026): August

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